Biotechnology is one of the most important future-technologies. Especially the development of modern biocatalysts to replace chemical synthesis for the production of API's and fine-chemicals by environmental benign, costs reducing and resource- and energy-saving processes is a strong growing and innovative sphere of activity. Furthermore bioactive natural compounds, mainly produced by the soil bacteria of the order Actinomycetales, are the origin of many commercial important drugs e.g. antibiotics, chemotherapeutics, immunosuppressants or enzyme inhibitors.
The rational strain development for the construction of efficient and exclusive industrial producer strains is the competence of W42.
Applying state of the art technology W42 has realized the high-yield production of important technical enzymes in Pichia sp. to enable efficient biocatalytic processes for the production of important intermediates for the synthesis of advanced β–Lactam antibiotics. In comparison to established processes we achieved a noticeable efficiency increase together with an explicit reduction of costs.
Using state of the art technologies W42 is able to optimise the capacity and productivity of your natural producer strains. By knock-out selected genes and/or integration of new genes/promoters the metabolism of bacteria is directed to high-production of your API or fine-chemical.
W42 has experience in genetic engineering of a broad range of bacteria e.g. Actinomycetes, Methylobacteria, Lactobacillus, E. coli …..
W42 are experts on the molecular biology of natural compounds including e.g. the identification of the corresponding gene clusters by specific screening methods and the cloning in genetically accessible host organisms. The rational strain development to realize the efficient and high-yield production of your active agent is our competence.
W42 is your partner for the successful development of industrial processes.
We can offer the development of complete processes including following topics:
Enzyme technology
Natural compounds
Rational strain development
