Natural compounds

W42 has a long standing experience in the biology of the important soil bacteria of the order Actinomycetales.

Characterisation of biosynthetic pathways

The elucidation of the biochemical basics for the biosynthesis of selected natural compounds by state of the art molecular techniques is a prerequisite to run rational strain improvement programs for the optimisation of product yield and pattern. By molecular characterisation e.g. DNA sequencing of the corresponding gene cluster W42 enable freedom to operate for our partners by filing the necessary patents.

Rational strain improvement

The analysis of the biosynthetic pathways including the concerned complex regulative networks and the biochemical characterisation of selected biosynthetic enzymes enable the understanding of the biosynthesis of the complex natural products with the manifold biological activities. For a rational strain improvement W42 can change the capacity of industrial producer strains by genetic engineering for the optimisation of product yield and pattern.